ABSTRACT. Aleutian disease virus (ADV) and closely related (ADV-like) viruses are Parvoviridae members (genus Amdoparvovirus) that primarily infect farmed mustelids and have been detected in humans and free-ranging Carnivora from North America. We describe ADV-like/Amdoparvovirus sp. infection in four free-ranging striped skunks (Mephitis mephitis) from the Midwestern US. © 2018, © Wildlife Disease Association 2018.