Weighting strategies for single-step genomic BLUP: An iterative approach for accurate calculation of GEBV and GWAS.

ABSTRACT. Genomic Best Linear Unbiased Predictor (GBLUP) assumes equal variance for all single nucleotide polymorphisms (SNP). When traits are influenced by major SNP, Bayesian methods have the advantage of SNP selection. To overcome the limitation of GBLUP, unequal variance or weights for all SNP are applied in a method called weighted GBLUP (WGBLUP). If only a fraction of animals is genotyped, single-step WGBLUP (WssGBLUP) can be used. Default weights in WGBLUP or WssGBLUP are obtained iteratively based on single SNP effect squared (u2) and/or heterozygosity.