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A major question facing global rice systems is the extent to which yield and resource use efficiency indicators can be simultaneously optimized to sustainably meet future food demand. However, research approaches for evaluating synergies and tradeoffs among multiple indicators have been limited to date. Using the case study of rice production in Uruguay, we quantified five cropping system performance indicators at the farm-level from 2012 to 2017, covering approximately 40% of national rice area.