Enzootic calcinosis in ruminants:A review.

ABSTRACT:Enzootic calcinosis (EC), is a chronic disease, caused by toxic plants, which has mainly affected ruminants for more than 100 years. It is characterized by a soft tissue calcification, hypercalcemia, hyperphosphatemia, hypoparathiroidism, hypercalcitoninism, osteonecrosis, and osteopetrosis. The toxic compound reported in some of these plants are 1,25(OH)2D3 glycosides. Characterization of calcinogenic principles were performed with Solanum glaucophyllum, Trisetum flavescens, Cestrum diurnum, and Stenotaphrum secundatum.